Outside linebacker Dee Ford will miss his second straight game, the Chiefs announced on Friday.
Ford suffered a back injury against the Chargers two weeks ago.
Also not playing on Sunday at Houston are offensive lineman Laurent Duvernay-Tardif and Mitch Morse.
Duvernay-Tardif suffered a sprained knee against Washington. Morse will miss his third game with a foot injury.
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The Chiefs listed four others on the injury report. All were full practice participants on Friday and will play Sunday: quarterback Alex Smith (ankle), defensive tackle Bennie Logan (knee), offensive tackle Eric Fisher (back) and linebacker Kevin Pierre-Louis (groin).